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Michel Slotman

Slotman, Michel
Michel Slotman
Associate Professor
Heep Center, Room 510
(979) 845-1885
Undergraduate Education
B.Sc., Biology Wageningen Agricultural University, The Netherlands 1997
Graduate Education
Post-Doctoral Associate, Dept. of Ecol. and Evol. Biol., Yale University 2005-2007
Post-Doctoral Fellow, Dept. of Entomology, University of California at Davis 2003-2005
Ph.D., Ecol. & Evol. Biology, Yale University, New Haven 2003
M.Ph., Biology, Yale University, New Haven 2000
M.S., Biology Yale University, New Haven 1999
M.S., Biology, Wageningen Agricultural University, The Netherlands 1997

Broadly speaking, my research concerns the evolutionary and population genetics of medically important insects, with a strong focus on Anopheles mosquitoes. Within this broader topic, a primary interest of mine has been the process of speciation in the Anopheles gambiae complex, a group of morphologically largely identical species which contains the two major malaria vectors of sub-Saharan Africa; Anopheles gambiae and An. arabiensis. Some of my work has focused on the accumulation of isolation or speciation genes between Anopheles gambiae s.s and An. arabiensis, and the effect that such genes have on the ability of these occasionally hybridizing species to exchange genetic material. Other work of mine has concerned the differentiation between and within the so-called molecular forms of An. gambiae s.s., with a particular emphasis on the role of reduced recombination and inversions in facilitating isolation between populations and forms. I have also worked on the evolution of anti-malarial immunity genes in mosquitoes.

Currently, I am undertaking several research projects in Equatorial Guinea in collaboration with Adalgisa Caccone, Michael Reddy and Jeffrey Powell from Yale University. These projects deal with the effects of a nation-wide control program, administered by Medical Care Development International (MCDI) and Marathon Oil company, on the population structure and biology of malaria vectors. In particular, I am interested in the effect of large-scale control on the effective size of mosquito populations, and the migration and population structure of An. melas, a malaria vector with a patchy distribution. I am also developing a research project exploring the genetic basis of the strong preference of An. gambiae for human blood meals.

Selected and recent publications:

Hodges TK, G Athrey, KC Deitz, HJ Overgaard, A Matias, A Caccone, MA Slotman (2013). Large fluctuations in the effective population size of the malaria mosquito Anopheles gambiae s.s. during vector control cycle. Evolutionary Applications 6 (8): 1171-1183. http://onlinelibrary.wiley.com/doi/10.1111/eva.12094/abstract

Reddy MR, A Godoy, K Dion, A Matias, K Callender, AE Kiszewksi, I Kleinschmidt, F Ridl, JR Powell, A, Caccone, and MA Slotman (2013) Insecticide resistance allele frequencies in Anopheles gambiae before and after anti-vector interventions in continental Equatorial Guinea. The American Journal of Tropical Medicine and Hygiene 88: 897-907 http://www.ajtmh.org/content/88/5/897.long

The Effective Population Size of Malaria Mosquitoes: Large Impact of Vector Control (2012) Athrey G, TK Hodges, MR Reddy, HJ Overgaard, A Matias, FC Ridl, I Kleinschmidt, A Caccone, MA Slotman. PLoS Genetics 8(12): e1003097.

Malaria transmission after 5 years of vector control on Bioko Island, Equatorial Guinea (2012) Overgaard HJ, VP Reddy, S Abaga, A Matias, MR Reddy, V Kulkarni, C Schwabe, L Segura, I Kleinschmidt, MA Slotman (2012)  Parasites and Vectors 5: 253

Genetic Isolation within the Malaria Mosquito Anopheles melas (2012) Deitz KC, G Athrey, MR Reddy, HJ Overgaard, A Matias, J Musa, A della Torre, J Pinto, A Kiszewski, C Costantini, A Caccone and MA Slotman.  Molecular Ecology 21: 4498-4513.

Limited Usefulness of Microsatellite Markers from the Malaria Vector Anopheles gambiae when Applied to the Closely Related Species An. melas (2012) Deitz KC, VP Reddy, MR Reddy, N Satyanarayanah, M Lindsey, HJ Overgaard, J Musa, A Caccone and MA Slotman.  Journal of Heredity 103: 585-593

Outdoor host-seeking behaviour of Anopheles gambiae mosquitoes following initiation of malaria vector control on Bioko Island, Equatorial Guinea (2011) Reddy MR, HJ Overgaard, S Abaga, VP Reddy, A Caccone, AE Kiszewski, MA Slotman. Malaria Journal 10: 184

Patterns of  selection in anti-malarial immune genes in malaria vectors: evidence for  adaptive evolution in LRIM1 in Anopheles arabiensis (2007) Slotman MA, A Parmakelis, JC Marshall, PH Awono-Ambene, C Antonio-Nkondjo, F Simard, A Caccone and JR Powell. PLoS One 2(8): e793.

Evidence for subdivision within the M molecular form of Anopheles gambiae s.s. (2007) Slotman MA , F Tripet, AJ Cornel, CR Meneses, Y Lee, LJ Reimer, TC Thieman, E Fondjo, A Fofana, SF Traoré and GC Lanzaro. Molecular Ecology 16: 639-649.

Reduced recombination rate and genetic differentiation between the M and S forms of Anopheles gambiae. (2006) Slotman MA, L Reimer, T Thiemann, G Dolo, E Fondjo, and GC Lanzaro.  Genetics 174: 2081-2093.